NFL Week 10 Picks Preview 2026
Week 10 opens Thursday night with the Commanders at the Giants in the rain. On Sunday, the Patriots and Lions play in Munich and the 49ers visit Dallas in the late window. Quarterback injuries shape the whole card: Deshaun Watson is out in Cleveland, Gardner Minshew is doubtful in Arizona, and Lamar Jackson is on injured reserve before Baltimore hosts the Chargers on Monday night. We compared the five offshore books, and these are the five sides we're betting, plus four bonus plays.
Pick | Bet Type | Line | Best Book | Confidence |
|---|---|---|---|---|
Rams -9.5 at Cardinals | Spread | -9.5 (-108) | Bovada | High |
49ers -3.5 at Cowboys | Spread | -3.5 (-114) | BetOnline | High |
Jaguars -10.5 at Titans | Spread | -10.5 (-110) | BetOnline | Medium-High |
Texans -5 at Browns | Spread | -5 (-108) | BetOnline | Medium |
Giants -1.5 vs. Commanders | Spread | -1.5 (-122) | BetOnline | Medium |
Los Angeles Rams at Arizona Cardinals
Arizona's offense is badly short-handed. Gardner Minshew is doubtful with a torn elbow ligament, and Michael Wilson is out for the season with a neck fracture. James Conner and Jeremiyah Love are both on injured reserve. The offensive line is also missing Paris Johnson Jr., Jon Gaines II and Jayden Williams. The Cardinals scored three points in Seattle last week and are 3-6 straight up.
The Rams are 5-4 against the spread and won 20-13 in Washington last week. All five books hang -9.5, so the value is in the price: Bovada charges -108, while BetOnline asks -113 and Everygame -116. Take the Rams -9.5 at -108 at Bovada.
The risk is the number. Nearly ten points is a lot to lay in a divisional game, and a backdoor cover is possible. But this Arizona offense has to show it can score before we worry about that.
San Francisco 49ers at Dallas Cowboys
San Francisco is 7-1 after beating the Raiders 38-17 and is 5-3 against the spread. Dallas will be missing its top two pass catchers, George Pickens and Jake Ferguson, plus CB Joey Porter Jr. RB Tyler Goodson is also out for multiple weeks.
BetOnline is the only book dealing 49ers -3.5 at -114. Bovada, Lucky Rebel and Everygame all have -4. That half-point is the reason to bet it at BetOnline.
The risk is a shootout. The total sits at 55.5 to 56, and Dallas put up 27 in Indianapolis last week. A late Cowboys touchdown could cut a comfortable lead to a field goal.
Jacksonville Jaguars at Tennessee Titans
Jacksonville went into Baltimore and won 33-10. The Jaguars were 5-2 against the spread through Week 8 and have covered their last four games as a road favorite. They also have extra rest after playing last Thursday. The last time these teams met, in Week 18 of 2025, Jacksonville won 41-7. Tennessee is 1-7.
All five books have -10.5, but BetOnline charges a flat -110 while Bovada and Lucky Rebel ask -112. Take the Jaguars -10.5 at -110 at BetOnline.
The risks: Tennessee is coming off a bye, and Jacksonville has lost OT Anton Harrison to a torn ACL. Double digits on the road always leaves room for a backdoor cover, but the Jaguars are the better team by a wide margin.
Houston Texans at Cleveland Browns
Deshaun Watson is out for Cleveland. Houston arrives after scoring 44 points against the Chargers. Cleveland is 5-4 and lost 23-22 in overtime in New Orleans last week. The Browns are also missing DT Maliek Collins and LB Jeremiah Owusu-Koramoah.
The spread is -5 everywhere. BetOnline offers -108, the cheapest price available, so we're betting the Texans -5 there.
The risk is Cleveland's record against the number. The Browns are 6-3 against the spread, Houston will be without RB David Montgomery, and we don't have a game-day forecast for the lakefront yet. We still trust Houston's offense more than a Browns team without its starting quarterback.
Washington Commanders at New York Giants
The Giants are 5-2-1 and 6-2 against the spread. They won 19-11 in Philadelphia last week. Washington is 2-5-1 and lost at home to the Rams. The forecast calls for rain at MetLife on Thursday night, which helps the more consistent team in a game with a total of 42.
The spread runs from Giants -1.5 at BetOnline to -2.5 at Everygame. Laying a full point less is worth the extra juice, so we're betting the Giants -1.5 at -122 at BetOnline.
The risk: both teams are on a short week in a division game, and the Commanders are 7-8-1 against New York since 2018. At this small a number, we only need the Giants to win by two.
Bonus Picks
- Chargers/Ravens Under 38.5 (-110) @ BetOnline - Lamar Jackson and Tyler Huntley are both on IR, Justin Herbert is questionable, and a cold front is heading for Baltimore.
- Steelers +3.5 (-111) @ BetOnline - Pittsburgh is 6-2 against the spread with four straight covers and comes in off a bye.
- Dolphins +2.5 (-108) @ Bovada - Indianapolis allows 27.8 points per game (30th) and lost WR Alec Pierce, and Bovada gives you 1.5 more points than BetOnline.
- Chiefs -3 (-117) @ BetOnline - Kansas City allows 17.9 points per game (3rd) and faces an Atlanta team that is 3-6 against the spread; check Mahomes' elbow before kickoff.
All picks are for entertainment purposes only. Please gamble responsibly.